Welcome to the blog

Scientific Evidence on the efficacy of botox for Chronic Migraine BOTULINUM TOXIN A Systematic reviews on the efficacy of botulinum toxin A are based mainly on two large multicentre RCTs, the Phase III Research Evaluating Migraine Prophylaxis Therapy (PREEMPT) 1 and PREEMPT 2. Both trials were conducted in patients with chronic migraine over 24 weeks. Patients received two sets of injections at 12 week intervals, followed by an open label phase.46,66,67 In PREEMPT 1 the primary endpoint of reduction in headache episodes from baseline compared to placebo was negative. However, there was significant reduction in secondary endpoints of headache days